MET monoclonal antibody, clone 6AT203
产品名称： MET monoclonal antibody, clone 6AT203
英文名称： MET monoclonal antibody, clone 6AT203
产品编号： MAB1144
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against partial recombinant MET.
- Immunogen:
- Recombinant protein corresponding to catalytic region of human MET.
- Host:
- Mouse
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Isotype:
- IgG1
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- MET receptor sequence variants R970C and T992I lack transforming capacity.
Tyner JW, Fletcher LB, Wang EQ, Yang WF, Rutenberg-Schoenberg ML, Beadling C, Mori M, Heinrich MC, Deininger MW, Druker BJ, Loriaux MM.Cancer Res. 2010 Aug 1;70(15):6233-7.
- 2.
- Further evidence for the role of MET in autism susceptibility.
Thanseem I, Nakamura K, Miyachi T, Toyota T, Yamada S, Tsujii M, Tsuchiya KJ, Anitha A, Iwayama Y, Yamada K, Hattori E, Matsuzaki H, Matsumoto K, Iwata Y, Suzuki K, Suda S, Kawai M, Sugihara G, Takebayashi K, Takei N, Ichikawa H, Sugiyama T, Yoshikawa T, Mori N.Neurosci Res. 2010 Oct;68(2):137-41. Epub 2010 Jul 6.
- 3.
- Increased HGF and c-Met in muscle tissues of polymyositis and dermatomyositis patients: beneficial roles of HGF in muscle regeneration.
Sugiura T, Kawaguchi Y, Soejima M, Katsumata Y, Gono T, Baba S, Kawamoto M, Murakawa Y, Yamanaka H, Hara M.Clin Immunol. 2010 Sep;136(3):387-99. Epub 2010 May 23.
- Applications
- Western Blot (Cell lysate)
- Detection of endogenous MET in HepG2 cell line. 10 ug/lane of HepG2 cell lysate was used to examine the expression of human MET. Lanes 1-5 represent MET monoclonal antibody, clone 6AT203 (Cat # MAB1144). Lane 6 represents auto-phosohorylated-MET in HepG2 cell line detected by anti-phospho-MET monoclonal antibody (Cat # MAB0115).
- Entrez GeneID:
- 4233
- Protein Accession#:
- P08581
- Gene Name:
- MET
- Gene Alias:
- AUTS9,HGFR,RCCP2,c-Met
- Gene Description:
- met proto-oncogene (hepatocyte growth factor receptor)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- HGF receptor,OTTHUMP00000069168,SF receptor,met proto-oncogene,met proto-oncogene tyrosine kinase,oncogene MET,scatter factor receptor
- Interactome
- Related Disease
- Adenocarcinoma
- Autistic Disorder
- Carcinoma, Adenosquamous
- Carcinoma, Large Cell
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Cell Transformation, Neoplastic
- Child Development Disorders, Pervasive
- Chronic Disease
- Cognition Disorders
- Disease Progression
- Gastrointestinal Diseases
- Genetic Predisposition to Disease
- Head and Neck Neoplasms
- Hyperparathyroidism, Secondary
- Lung Neoplasms
- Myopia
- Nasal Polyps
- Neoplasm Metastasis