Anti-RAF1 Polyclonal Antibody-抗体-抗体-生物在线
北京索莱宝科技有限公司--实验室产品
Anti-RAF1 Polyclonal Antibody

Anti-RAF1 Polyclonal Antibody

商家询价

产品名称: Anti-RAF1 Polyclonal Antibody

英文名称: CMD1NN;CRAF;NS5;Raf-1;c-Raf

产品编号: K000318P

产品价格: null

产品产地: 北京

品牌商标: Solarbio

更新时间: null

使用范围: WB IHC IF

北京索莱宝科技有限公司--实验室产品
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This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.