BMP4 polyclonal antibody
产品名称: BMP4 polyclonal antibody
英文名称: BMP4 polyclonal antibody
产品编号: PAB3673
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of BMP4.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human BMP4.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Identification of a putative autocrine bone morphogenetic protein-signaling pathway in human ovarian surface epithelium and ovarian cancer cells.
Shepherd TG, Nachtigal MW.Endocrinology. 2003 Aug;144(8):3306-14.
- 2.
- Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress stimulates an inflammatory response.
Sorescu GP, Sykes M, Weiss D, Platt MO, Saha A, Hwang J, Boyd N, Boo YC, Vega JD, Taylor WR, Jo H.J Biol Chem. 2003 Aug 15;278(33):31128-35. Epub 2003 May 23.
- 3.
- Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells.
Chadwick K, Wang L, Li L, Menendez P, Murdoch B, Rouleau A, Bhatia M.Blood. 2003 Aug 1;102(3):906-15. Epub 2003 Apr 17.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of MDA-MB-435 cell lysate (35 ug/lane) with BMP4 polyclonal antibody (Cat # PAB3673).
- Western Blot (Transfected lysate)
- Western blot analysis of BMP4 (arrow) using BMP4 polyclonal antibody (Cat # PAB3673).
293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the BMP4 gene (Lane 2).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with BMP4 polyclonal antibody (Cat # PAB3673) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated.
- Entrez GeneID:
- 652
- Protein Accession#:
- NP_001193
- Gene Name:
- BMP4
- Gene Alias:
- BMP2B,BMP2B1,MCOPS6,ZYME
- Gene Description:
- bone morphogenetic protein 4
- Omim ID:
- 112262
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq
- Other Designations:
- bone morphogenetic protein 2B
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Anemia, Sickle Cell
- Bone Diseases
- Bone Diseases, Metabolic
- Calcinosis
- Cardiovascular Diseases
- Cleft Lip
- Cleft Palate
- Coloboma
- Colorectal Neoplasms
- Diabetes Complications
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Diabetic Nephropathies
- Disease Susceptibility
- Edema
- Gaucher Disease
- Gaucher disease