RNF187,环指蛋白187抗体

产品编号HZ-9283R
英文名称RNF187
中文名称环指蛋白187抗体
别 名E3 ubiquitin-protein ligase RNF187; Protein RNF187; RACO-1; RING domain AP1 coactivator 1; RING finger protein 187; RN187_HUMAN; RNF187.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Cow, Rabbit,
RNF187,环指蛋白187抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量26kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human RNF187
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
RNF187,环指蛋白187抗体PubMedPubMed
产品介绍background:
E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.

Function:
E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.

Subunit:
Interacts with JUN, independently of JUN phosphorylation.

Subcellular Location:
Cytoplasm. Nucleus. Predominantly located in the cytoplasm. Shuttles between the cytoplasm and the nucleus.

Post-translational modifications:
Ubiquitinated; undergoes 'Lys-48'-linked autoubiquitination in the absence of growth factors and MAP3K1-induced 'Lys-63'-linked polyubiquitination. 'Lys-48'-autoubiquitination leads to degradation by the proteasome, while MAP3K1-induced 'Lys-63'-linked polyubiquitination results in the stabilization of the protein. 'Lys-48'- and 'Lys-63'-linked polyubiquitinations occur most probably on the same 3 C-terminal lysine residues (Lys-195, Lys-223 and Lys-224) and are thus mutually exclusive. Other sites of ubiquitination are not excluded.

Similarity:
Contains 1 RING-type zinc finger.

Gene ID:
149603

RNF187,环指蛋白187抗体Database links:
Entrez Gene: 149603 Human
Entrez Gene: 108660 Mouse
Entrez Gene: 360533 Rat
SwissProt: Q5TA31 Human
SwissProt: Q8BFX1 Mouse
SwissProt: D3Z8N2 Rat
Unigene: 356377 Human
Unigene: 679030 Human
Unigene: 249986 Mouse
Unigene: 100245 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.