SMAD3 polyclonal antibody
产品名称： SMAD3 polyclonal antibody
英文名称： SMAD3 polyclonal antibody
产品编号： PAB1987
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of SMAD3.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to internal region residues surrounding N206 of human SMAD3.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Roles for lysine residues of the MH2 domain of Smad3 in transforming growth factor-beta signaling.
Imoto S, Sugiyama K, Sekine Y, Matsuda T.FEBS Lett. 2005 May 23;579(13):2853-62. Epub 2005 Apr 26.
- 2.
- TGFbeta1/Smad3 counteracts BRCA1-dependent repair of DNA damage.
Dubrovska A, Kanamoto T, Lomnytska M, Heldin CH, Volodko N, Souchelnytskyi S.Oncogene. 2005 Mar 31;24(14):2289-97.
- 3.
- Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding protein/p300 recruitment.
Furumatsu T, Tsuda M, Taniguchi N, Tajima Y, Asahara H.J Biol Chem. 2005 Mar 4;280(9):8343-50. Epub 2004 Dec 28.
- Entrez GeneID:
- 4088
- Protein Accession#:
- NP_005893;P84022
- Gene Name:
- SMAD3
- Gene Alias:
- DKFZp586N0721,DKFZp686J10186,HSPC193,HsT17436,JV15-2,MADH3,MGC60396
- Gene Description:
- SMAD family member 3
- Omim ID:
- 603109
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq
- Other Designations:
- MAD, mothers against decapentaplegic homolog 3,SMA- and MAD-related protein 3,SMAD, mothers against DPP homolog 3,mad homolog JV15-2,mad protein homolog,mothers against decapentaplegic homolog 3
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Anemia, Sickle Cell
- Anemia, sickle cell
- Asthma
- Bacteremia
- Breast cancer
- Breast Neoplasms
- Cleft Lip
- Cleft Palate
- Coronary Artery Disease
- Crohn Disease
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Diabetic Nephropathies
- Genetic Predisposition to Disease
- Graft vs Host Disease
- Head and Neck Neoplasms
- Hypersensitivity