HSPA1A monoclonal antibody, clone 4E7
产品名称： HSPA1A monoclonal antibody, clone 4E7
英文名称： HSPA1A monoclonal antibody, clone 4E7
产品编号： MAB1094
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against full length recombinant HSPA1A.
- Immunogen:
- Recombinant protein corresponding to full length human HSPA1A.
- Host:
- Mouse
- Reactivity:
- Human
- Form:
- Liquid
- Isotype:
- IgG1, kappa
- Storage Buffer:
- In PBS, pH 7.4 (0.1% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:1000-1:2000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Proteomic study identified HSP 70kDa protein 1A as a possible therapeutic target, in combination with histone deacetylase inhibitors, for lymphoid neoplasms.
Fujii K, Suzuki N, Ikeda K, Hamada T, Yamamoto T, Kondo T, Iwatsuki K.J Proteomics. 2011 Nov 20.
- 2.
- The chaperone function of hsp70 is required for protection against stress-induced apoptosis.
Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B.Mol Cell Biol. 2000 Oct;20(19):7146-59.
- 3.
- Protein folding in the cell.
Gething MJ, Sambrook J.Nature. 1992 Jan 2;355(6355):33-45.
- 4.
- Involvement of ATP in the nuclear and nucleolar functions of the 70 kd heat shock protein.
Lewis MJ, Pelham HR.EMBO J. 1985 Dec 1;4(12):3137-43.
- Applications
- Western Blot (Cell lysate)
- Western blot of JAR cell lysate (25 ug/lane) with HSPA1A monoclonal antibody, clone 4E7 (Cat # MAB1094).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Paraffin embedded sections of human eccrine gland were incubated with HSPA1A monoclonal antibody , clone 4E7 (Cat # MAB1094) (1:100) for 2 hours at room temperature. Antigen retrieval was performed in 0.1M sodium citrate buffer and detected using Diaminobenzidine (DAB).
- Entrez GeneID:
- 3303
- GeneBank Accession#:
- NM_005345
- Protein Accession#:
- NP_005336
- Gene Name:
- HSPA1A
- Gene Alias:
- FLJ54303,FLJ54370,FLJ54392,FLJ54408,FLJ75127,HSP70-1,HSP70-1A,HSP70I,HSP72,HSPA1,HSPA1B
- Gene Description:
- heat shock 70kDa protein 1A
- Omim ID:
- 140550
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq
- Other Designations:
- OTTHUMP00000029287,dnaK-type molecular chaperone HSP70-1,heat shock 70kD protein 1A,heat shock 70kDa protein 1B,heat shock-induced protein
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