FITC标记的组织相容性复合体蛋白1抗体
产品名称： FITC标记的组织相容性复合体蛋白1抗体
英文名称： Anti-MHC class I/HLA-C/FITC
产品编号： HZ-10251R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MHC class I/HLA-C/FITC Conjugated antibody
FITC标记的组织相容性复合体蛋白1抗体
| 英文名称 | Anti-MHC class I/HLA-C/FITC |
| 中文名称 | FITC标记的组织相容性复合体蛋白1抗体 |
| 别 名 | 1C07_HUMAN; Cw-7 alpha chain; D6S204; HLA class I histocompatibility antigen; HLA class I histocompatibility antigen, C alpha chain; HLA class I histocompatibility antigen, Cw-1 alpha chain; HLA-C; HLA-C histocompatibility type; HLA-Cw; HLA-JY3; HLAC; HLC-C; human leukocyte antigen-C alpha chain; major histocompatibility antigen HLA-C; major histocompatibility complex, class I, C; MHC class I antigen; MHC class I antigen Cw 1; MHC class I antigen Cw*7; MHC class I antigen heavy chain HLA-C; PSORS1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 45kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MHC class I |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008] Function: Involved in the presentation of foreign antigens to the immune system. Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein. Interacts with HTLV-1 p12I accessory protein. Subcellular Location: Cell Membrane; Type I membrane protein. Post-translational modifications: Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system. Similarity: Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain. Database links:
Entrez Gene: 3107 Human Omim: 142840 Human SwissProt: P04222 Human SwissProt: P10321 Human SwissProt: Q07000 Human Unigene: 656020 Human Unigene: 743218 Human Unigene: 77961 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
HLA-A属于HLAⅠ类重链同源物。这类I分子是由重链和轻链（β-2微球蛋白）组成的异源二聚体。重链被锚定在膜中。I类分子通过呈现来自内质网腔的肽在免疫系统中发挥中心作用。它们几乎在所有的细胞中表达。重链约45 kDa，其基因含有8个外显子。外显子1编码前导肽，外显子2和3编码α1和α2结构域，它们结合肽，外显子4编码α3结构域，外显子5编码跨膜区，外显子6和7编码胞质尾。外显子2和外显子3的多态性对每个一类分子的肽结合特异性负责。骨髓和肾移植通常进行这些多态性的分型。已经描述了数以百计的HLA-A等位基因。[ RefSeq，JUL 2008 ]