CPSF4 MaxPab mouse polyclonal antibody (B02)
产品名称： CPSF4 MaxPab mouse polyclonal antibody (B02)
英文名称： CPSF4 MaxPab mouse polyclonal antibody (B02)
产品编号： H00010898-B02
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse polyclonal antibody raised against a full-length human CPSF4 protein.
- Immunogen:
- CPSF4 (AAH50738, 1 a.a. ~ 243 a.a) full-length human protein.
- Sequence:
- MQEIIASVDHIKFDLEIAVEQQLGAQPLPFPGMDKSGAAVCEFFLKAACGKGGMCPFRHISGEKTVVCKHWLRGLCKKGDQCEFLHEYDMTKMPECYFYSKFGECSNKECPFLHIDPESKIKDCPWYDRGFCKHGPLCRHRHTRRVICVNYLVGFCPEGPSCKFMHPRFELPMGTTEQPPLPQQTQPPAKRTPQVIGVMQSQNSSAGNRGPRPLEQVTCYKCGEKGHYANRCTKGHLAFLSGQ
- Host:
- Mouse
- Reactivity:
- Human
- Storage Buffer:
- No additive
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody reactive against mammalian transfected lysate.
- Note:
- For IHC and IF applications, antibody purification with Protein A will be needed prior to use.
- MSDS:
Download
- Applications
- Western Blot (Transfected lysate)
- Western Blot analysis of CPSF4 expression in transfected 293T cell line (H00010898-T02) by CPSF4 MaxPab polyclonal antibody.
Lane 1: CPSF4 transfected lysate(26.73 KDa).
Lane 2: Non-transfected lysate. - Protocol Download
- Entrez GeneID:
- 10898
- GeneBank Accession#:
- BC050738
- Protein Accession#:
- AAH50738
- Gene Name:
- CPSF4
- Gene Alias:
- CPSF30,NAR,NEB1
- Gene Description:
- cleavage and polyadenylation specific factor 4, 30kDa
- Omim ID:
- 603052
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq
- Other Designations:
- cleavage-polyadenylation specificity factor, 30kD,no arches-like zinc finger protein
- Related Disease