TP53I3 monoclonal antibody, clone 10A2
产品名称： TP53I3 monoclonal antibody, clone 10A2
英文名称： TP53I3 monoclonal antibody, clone 10A2
产品编号： MAB1974
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against recombinant TP53I3.
- Immunogen:
- Recombinant protein of human TP53I3.
- Host:
- Mouse
- Reactivity:
- Human
- Form:
- Liquid
- Isotype:
- IgG1
- Storage Buffer:
- In PBS (0.08% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
- Recommend Usage:
- Western blot (5 to 10 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest.
Flatt PM, Polyak K, Tang LJ, Scatena CD, Westfall MD, Rubinstein LA, Yu J, Kinzler KW, Vogelstein B, Hill DE, Pietenpol JA.Cancer Lett. 2000 Aug 1;156(1):63-72.
- 2.
- The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression.
Venot C, Maratrat M, Dureuil C, Conseiller E, Bracco L, Debussche L.EMBO J. 1998 Aug 17;17(16):4668-79.
- 3.
- Regulation of p53 downstream genes.
el-Deiry WS.Semin Cancer Biol. 1998;8(5):345-57.
- Entrez GeneID:
- 9540
- Gene Name:
- TP53I3
- Gene Alias:
- PIG3
- Gene Description:
- tumor protein p53 inducible protein 3
- Omim ID:
- 605171
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. At least two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
- Other Designations:
- OTTHUMP00000116037,p53-induced gene 3 protein,quinone oxidoreductase homolog
- Gene Pathway
- Related Disease
- Adenocarcinoma
- Breast cancer
- Breast Neoplasms
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Hematologic Diseases
- Hodgkin Disease
- Lung Neoplasms
- Lymphoma, B-Cell
- Lymphoma, Follicular
- Lymphoma, Large B-Cell, Diffuse
- Lymphoproliferative Disorders
- Neoplasms, Glandular and Epithelial
- Occupational Diseases
- Ovarian cancer
- Ovarian Neoplasms
- Pulmonary Disease, Chronic Obstructive
- Urinary Bladder Neoplasms
- Waldenstrom Macroglobulinemia