ALDOA polyclonal antibody
产品名称: ALDOA polyclonal antibody
英文名称: ALDOA polyclonal antibody
产品编号: PAB2568
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ALDOA.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human ALDOA.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Evolutionary conserved N-terminal region of human muscle fructose 1,6-bisphosphatase regulates its activity and the interaction with aldolase.
Gizak A, Maciaszczyk E, Dzugaj A, Eschrich K, Rakus D.Proteins. 2008 Jul;72(1):209-16.
- 2.
- Involvement of aldolase A in X-ray resistance of human HeLa and UV(r)-1 cells.
Lu J, Suzuki T, Satoh M, Chen S, Tomonaga T, Nomura F, Suzuki N.Biochem Biophys Res Commun. 2008 May 9;369(3):948-52. Epub 2008 Mar 5.
- 3.
- VDAC2 and aldolase A identified as membrane proteins of K562 cells with increased expression under iron deprivation.
Valis K, Neubauerova J, Man P, Pompach P, Vohradsky J, Kovar J.Mol Cell Biochem. 2008 Apr;311(1-2):225-31. Epub 2008 Feb 17.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of ALDOA polyclonal antibody (Cat # PAB2568) in CEM cell line lysates (35 ug/lane). ALDOA (arrow) was detected using the purified polyclonal antibody (1 : 60 dilution).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human lung carcinomareacted with ALDOA polyclonal antibody (Cat # PAB2568), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 226
- Protein Accession#:
- NP_000025;P04075
- Gene Name:
- ALDOA
- Gene Alias:
- ALDA,MGC10942,MGC17716,MGC17767
- Gene Description:
- aldolase A, fructose-bisphosphate
- Omim ID:
- 103850
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene product, Aldolase A (fructose-bisphosphate aldolase) is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants which encode the same protein. [provided by RefSeq
- Other Designations:
- aldolase A,fructose-1,6-bisphosphate triosephosphate-lyase,fructose-bisphosphate aldolase A
- Gene Pathway
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Carbon fixation in photosynthetic organisms
- Fructose and mannose metabolism
- Glycolysis / Gluconeogenesis
- Metabolic pathways
- Pentose phosphate pathway
- Related Disease