RAD17 purified MaxPab mouse polyclonal antibody (B01P)
产品名称： RAD17 purified MaxPab mouse polyclonal antibody (B01P)
英文名称： RAD17 purified MaxPab mouse polyclonal antibody (B01P)
产品编号： H00005884-B01P
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse polyclonal antibody raised against a full-length human RAD17 protein.
- Immunogen:
- RAD17 (NP_579919.1, 1 a.a. ~ 584 a.a) full-length human protein.
- Sequence:
- MNQHELAVHKKKIEEVETWLKAQVLERQPKQGGSILLITGPPGCGKTTTLKILSKEHGIQVQEWINPVLPDFQKDDFKGMFNTESSFHMFPYQSQIAVFKEFLLRATKYNKLQMLGDDLRTDKKIILVEDLPNQFYRDSHTLHEVLRKYVRIGRCPLIFIISDSLSGDNNQRLLFPKEIQEECSISNISFNPVAPTIMMKFLNRIVTIEANKNGGKITVPDKTSLELLCQGCSGDIRSAINSLQFSSSKGENNLRPRKKGMSLKSDAVLSKSKRRKKPDRVFENQEVQAIGGKDVSLFLFRALGKILYCKRASLTELDSPRLPSHLSEYERDTLLVEPEEVVEMSHMPGDLFNLYLHQNYIDFFMEIDDIVRASEFLSFADILSGDWNTRSLLREYSTSIATRGVMHSNKARGYAHCQGGGSSFRPLHKPQWFLINKKYRENCLAAKALFPDFCLPALCLQTQLLPYLALLTIPMRNQAQISFIQDIGRLPLKRHFGRLKMEALTDREHGMIDPDSGDEAQLNGGHSAEESLGEPTQATVPETWSLPLSQNSASELPASQPQPFSAQGDMEENIIIEDYESDGT
- Host:
- Mouse
- Reactivity:
- Human
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody reactive against mammalian transfected lysate.
- MSDS:
Download
- Applications
- Western Blot (Transfected lysate)
- Western Blot analysis of RAD17 expression in transfected 293T cell line (H00005884-T01) by RAD17 MaxPab polyclonal antibody.
Lane 1: RAD17 transfected lysate(64.24 KDa).
Lane 2: Non-transfected lysate. - Protocol Download
- Entrez GeneID:
- 5884
- GeneBank Accession#:
- NM_133341
- Protein Accession#:
- NP_579919.1
- Gene Name:
- RAD17
- Gene Alias:
- CCYC,FLJ41520,HRAD17,R24L,RAD17SP,RAD24
- Gene Description:
- RAD17 homolog (S. pombe)
- Omim ID:
- 603139
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq
- Other Designations:
- OTTHUMP00000125189,OTTHUMP00000125190,OTTHUMP00000125192,OTTHUMP00000125193,OTTHUMP00000125194,RAD1 homolog,RAD17 homolog,RF-C activator 1 homolog,Rad17-like protein,cell cycle checkpoint protein (RAD17)
- Related Disease