EP300 (phospho S89) Peptide
产品名称： EP300 (phospho S89) Peptide
英文名称： EP300 (phospho S89) Peptide
产品编号： P1377
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of EP300.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S89 of human EP300.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Dot Blot (1:500)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53.
Dornan D, Eckert M, Wallace M, Shimizu H, Ramsay E, Hupp TR, Ball KL.Mol Cell Biol. 2004 Nov;24(22):10083-98.
- 2.
- The N-terminal interferon-binding domain (IBiD) homology domain of p300 binds to peptides with homology to the p53 transactivation domain.
Finlan L, Hupp TR.J Biol Chem. 2004 Nov 19;279(47):49395-405. Epub 2004 Aug 26.
- 3.
- Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation.
Jin YH, Jeon EJ, Li QL, Lee YH, Choi JK, Kim WJ, Lee KY, Bae SC.J Biol Chem. 2004 Jul 9;279(28):29409-17. Epub 2004 May 10.
- Applications
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with EP300 (phospho S89) polyclonal antibody (Cat # PAB0461) which was peroxidase-conjugated to the secondary antibody followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.
- Entrez GeneID:
- 2033
- Protein Accession#:
- NP_001420;Q09472
- Gene Name:
- EP300
- Gene Alias:
- KAT3B,p300
- Gene Description:
- E1A binding protein p300
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq
- Other Designations:
- E1A-associated protein p300,E1A-binding protein, 300kD,OTTHUMP00000028668,histone acetyltransferase p300
- Related Disease
- Breast cancer
- Breast Neoplasms
- Cardiovascular Diseases
- Diabetes Mellitus, Type 2
- Ductus Arteriosus, Patent
- Edema
- Genetic Predisposition to Disease
- Infant, Premature, Diseases
- Kidney Failure, Chronic
- Neoplasms, Glandular and Epithelial
- Ovarian cancer
- Ovarian Neoplasms
- Spinal Dysraphism
- Thyroid Neoplasms