FITC标记的磷酸化癌基因FOS蛋白B抗体
产品名称： FITC标记的磷酸化癌基因FOS蛋白B抗体
英文名称： Anti-phospho-Fos B (Ser27)/FITC
产品编号： HZ-13198R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
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Rabbit Anti-phospho-Fos B (Ser27)/FITC Conjugated antibody
FITC标记的磷酸化癌基因FOS蛋白B抗体
| 英文名称 | Anti-phospho-Fos B (Ser27)/FITC |
| 中文名称 | FITC标记的磷酸化癌基因FOS蛋白B抗体 |
| 别 名 | Fos B (phospho S27); p-Fos B (phospho S27); p-FosB (phospho S27); FBJ murine osteosarcoma viral oncogene homolog B; FOS B; FOS-B; FBJ osteosarcoma oncogene B; FosB; G0/G1 switch regulatory protein 3; G0S3; GOS3; GOSB; MGC42291; Oncogene FOS B; Protein fosB; fosB; G0/G1 switch regulatory protein 3; G0S3; GOS 3; GOS B; GOSB; Oncogene FOS B; Oncogene FOSB; Protein fos B; DKFZp686C0818; FOSB_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 细胞生物 免疫学 染色质和核信号 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Sheep, Guinea Pig, |
| 产品应用 | Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 36kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human Fos B around the phosphorylation site of Ser27 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The v-Fos oncogene was initially identified as the transforming gene of two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phosphoprotein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA TPA response elements (TREs), c-Fos proteins are only active as heterodimers with members of the Jun gene family. Murine Fos B encodes a nuclear protein of 338 amino acids which has 70% homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B which bind to TRE DNA response elements. Functional homologs of c-Fos and Fos B include Fra-1 and Fra-2 genes. Function: FosB interacts with Jun proteins enhancing their DNA binding activity. Subunit: Heterodimer. Subcellular Location: Nucleus. Similarity: Belongs to the bZIP family. Fos subfamily. Contains 1 bZIP (basic-leucine zipper) domain. Database links: Entrez Gene: 2354 Human Entrez Gene: 14282 Mouse Entrez Gene: 100360880 Rat Omim: 164772 Human SwissProt: P53539 Human SwissProt: P13346 Mouse Unigene: 590958 Human Unigene: 248335 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
v-Fos癌基因最初被鉴定为两个独立的鼠骨肉瘤病毒分离物和一种禽肾母细胞瘤病毒的转化基因。细胞同源物c-Fos编码一种核磷蛋白，该蛋白由多种试剂快速和瞬时诱导，并起多种基因的转录调节作用。与形成与特定DNA TPA应答元件(TRE)结合的同源和异源二聚体的c-Jun蛋白不同，c-Fos蛋白仅作为具有Jun基因家族成员的异源二聚体而具有活性。小鼠Fos B编码338个氨基酸的核蛋白，与c-Fos有70%的同源性，显示出与c-Fos相似的表达动力学，并与c-Jun和Jun B形成与TRE DNA响应元件结合的异二聚体。c-fos和Fos B的功能同源物包括FRA-1和FRA-2基因。