FITC标记的G蛋白偶联受体169抗体
产品名称： FITC标记的G蛋白偶联受体169抗体
英文名称： Anti-MRGPRG/FITC
产品编号： HZ-17758R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MRGPRG/FITC Conjugated antibody
FITC标记的G蛋白偶联受体169抗体
| 英文名称 | Anti-MRGPRG/FITC |
| 中文名称 | FITC标记的G蛋白偶联受体169抗体 |
| 别 名 | G protein coupled receptor 169; G protein coupled receptor MRGG; G-protein coupled receptor 169; GPR169; Mas related G protein coupled receptor member G; MAS related GPR member G; Mas-related G-protein coupled receptor member G; MRGG; MRGPRG; MRGRG_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 神经生物学 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 32kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MRGPRG |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: MRGG is a 289 amino acid multi-pass membrane protein that functions as an orphan receptor. A member of the G-protein coupled receptor 1 family and Mas subfamily, MRGG is implicated in pain sensation and modulation by regulating nociceptor function. The gene encoding MRGG maps to human chromosome 11, which comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes. Function: Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Subcellular Location: Cell membrane. Similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily. Database links: Entrez Gene: 386746 Human SwissProt: Q86SM5 Human Unigene: 730306 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
MRGG是一种作为孤儿受体功能的289氨基酸多通道膜蛋白。MRGG是G蛋白偶联受体1家族和Mas亚家族的成员，通过调节伤害感受器功能参与疼痛感觉和调节。编码MRGG的基因定位于人类11号染色体，该染色体约占人类基因组DNA的4％，被认为是基因和疾病关联的密集染色体。编码Atm基因的11号染色体对双链DNA断裂后细胞周期阻滞和凋亡的调控具有重要意义。ATM突变导致称为共济失调毛细血管扩张症。镰状细胞贫血和地中海贫血是由HBB基因突变引起的，而Wilms肿瘤、WAGR综合征和Denys-Drash综合征与WT1基因突变有关。Jervell和Lange-Nielsen综合征、Jac.n综合征、Niemann-Pick病、遗传性血管水肿和Smith-Lemli-Opitz综合征也与染色体11编码基因的缺陷有关。