STAT2 (phospho Y690) polyclonal antibody
产品名称： STAT2 (phospho Y690) polyclonal antibody
英文名称： STAT2 (phospho Y690) polyclonal antibody
产品编号： PAB11305
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of STAT2.
- Immunogen:
- Synthetic phosphopeptide corresponding to residues surrounding Y690 of human STAT2.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This affinity purified antibody is directed against human STAT2 pY690 protein.
- Form:
- Liquid
- Storage Buffer:
- In 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:85000)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling.
Li X, Leung S, Kerr IM, Stark GR.Mol Cell Biol. 1997 Apr;17(4):2048-56.
- Applications
- Western Blot (Cell lysate)
- Western blot using STAT2 (phospho Y690) polyclonal antibody (Cat # PAB11305) shows detection of STAT2 pY690 protein (arrowhead) in Jurkat cells without (left lane) and with (right lane) 1000 U/mL of IFN-alpha for 15 min at 37°C.
The primary antibody was used at 1 : 1,000.
Personal Communication, A.Gamero, NCI, Bethesda, MD.
- Entrez GeneID:
- 6773
- Protein Accession#:
- NP_005410;P52630
- Gene Name:
- STAT2
- Gene Alias:
- ISGF-3,MGC59816,P113,STAT113
- Gene Description:
- signal transducer and activator of transcription 2, 113kDa
- Omim ID:
- 600556
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. [provided by RefSeq
- Other Designations:
- interferon alpha induced transcriptional activator,signal transducer and activator of transcription 2
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