AHCY (C-term) Peptide
产品名称： AHCY (C-term) Peptide
英文名称： AHCY (C-term) Peptide
产品编号： P1223
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 所在区域 : 台湾
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of AHCY.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human AHCY.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 2. The role of helix 18 stability.
Li QS, Cai S, Fang J, Borchardt RT, Kuczera K, Middaugh CR, Schowen RL.Biochemistry. 2008 Apr 29;47(17):4983-91. Epub 2008 Apr 8.
- 2.
- Homocysteine-mediated expression of SAHH, DNMTs, MBD2, and DNA hypomethylation potential pathogenic mechanism in VSMCs.
Yideng J, Jianzhong Z, Ying H, Juan S, Jinge Z, Shenglan W, Xiaoqun H, Shuren W.DNA Cell Biol. 2007 Aug;26(8):603-11.
- 3.
- Isozyme and DNA analysis of human S-adenosyl-L-homocysteine hydrolase (AHCY).
Arredondo-Vega FX, Charlton JA, Edwards YH, Hopkinson DA, Whitehouse DB.Ann Hum Genet. 1989 May;53(Pt 2):157-67.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of AHCY polyclonal antibody (Cat # PAB2578) in HepG2 cell line lysates (35 ug/lane). AHCY (arrow) was detected using the purified polyclonal antibody (1 : 60 dilution).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human colon carcinomareacted with AHCY polyclonal antibody (Cat # PAB2578), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 191
- Protein Accession#:
- NP_000678;P23526
- Gene Name:
- AHCY
- Gene Alias:
- SAHH
- Gene Description:
- S-adenosylhomocysteine hydrolase
- Omim ID:
- 180960
- Gene Ontology:
- Hyperlink
- Gene Summary:
- S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- OTTHUMP00000030684,adenosylhomocysteinase
- Related Disease
- Aortic Aneurysm, Abdominal
- Brain Ischemia
- Cardiovascular Diseases
- Cleft Lip
- Cleft Palate
- Colorectal Neoplasms
- Depressive Disorder, Major
- Diabetes Mellitus, Type 2
- Edema
- Fatigue
- Genetic Predisposition to Disease
- Hyperhomocysteinemia
- Microsatellite Instability
- Sleep Disorders
- Sleep Initiation and Maintenance Disorders
- Spinal Dysraphism
- Stroke
- Tooth Abnormalities
- Venous Thrombosis