FITC标记的胶质细胞系源性神经营养因子受体α2抗体
产品名称： FITC标记的胶质细胞系源性神经营养因子受体α2抗体
英文名称： Anti-GDNF Receptor alpha 2/FITC
产品编号： HZ-0054R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-GDNF Receptor alpha 2/FITC Conjugated antibody
FITC标记的胶质细胞系源性神经营养因子受体α2抗体
| 英文名称 | Anti-GDNF Receptor alpha 2/FITC |
| 中文名称 | FITC标记的胶质细胞系源性神经营养因子受体α2抗体 |
| 别 名 | GDNF family receptor alpha-2; GDNF Receptor α2; GDNF receptor beta; GDNFR beta; GDNFR-beta; GDNFRB; GFR alpha 2; GFRA 2; GFRA2; GFR alpha-2; Glial cell line derived neurotrophic factor family receptor alpha2b; Glial cell line derived neurotrophic factor receptor beta; Neurturin receptor alpha; NRTNR alpha; NRTNR-alpha; NTNR alpha; NTNR-alpha; NTNRA; PI linked cell surface accessory protein; RET ligand 2; RETL 2; RETL2; TGF beta related neurotrophic factor receptor 2; TRN receptor GPI anchored; TRNR 2; TRNR2; GFRA2_HUMAN; GDNF family receptor alpha-2; GDNF receptor alpha-2; Short=GDNFR-alpha-2; GFR-alpha-2; Neurturin receptor alpha; TGF-beta-related neurotrophic factor receptor 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 发育生物学 神经生物学 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 47kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GDNF Receptor alpha 2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. Members of the glial cell line-derived neurotrophic factor(GDNF) family, including GDNF and neurturin (NTN),play key roles in the control of vertebrate neuron survivaland differentiation. Physiological responses to NTN requirethe presence of a novel glycosylphosphadidylinositollinked protein NTNRa, which is a cell surface receptor forNTN. The cDNAs encoding NTNRa from human, rat,chicken, and mouse have been cloned recently. NTNRa was also termed GDNFRb, Ret ligand 2 (RETL2)or TGF-b-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRa-2 recently. GFRa-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRa-2, and the Ret PTK form a complex to transduce NTN signal andto mediate NTN function. Function: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Tissue Specificity: Isoform 1 is found in both brain and placenta. Similarity: Belongs to the GDNFR family. Database links: Entrez Gene: 2675 Human Entrez Gene: 14586 Mouse Entrez Gene: 25136 Rat Omim: 601956 Human SwissProt: O00451 Human SwissProt: O08842 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神经生物学相关蛋白（Neurobiology） 胶质细胞源性神经营养因子(GDNF)是TGF-β家族的一个新亚族，该亚族还有新发现的三个成员：Neurturin(NTN)、Persephin(PSP)和Artemin(ART)，它们均不程度地对多巴胺神经元、脊髓前角运动神经元、背根神经节、颈上神经节以及肾等非神经元细胞都具有生长促进作用。研究表明胶质细胞系源性神经营养因子,主要用于PD的研究。 GDNF的受体是多成分的复合物，它是由固定于质膜外层的糖基磷脂酰肌醇(GPI)被称为GDNFRα和酪氨酸激酶RET蛋白组成。GDNFRα为其配体结合亚单位，而RET则是GDNF的功能性受体亚单位，即GDNF特异地结合于其受体的GDNFRα上，再激活RET的酪氨酸磷酸化传导其信号，影响细胞的活性，发挥其生物学效应。目前，又克隆出了人与大鼠的GDNFRβ序列，与GDNPRα具有47％的同源性。GDNFRβ mRNA在脊髓、DRG和发育中的周围神经上也均有表达 |
胶质细胞源性神经营养因子（GDNF）和神经尿（NTN）是两个结构相关的、功能强大的神经营养因子，在控制神经元的存活和分化中起着关键作用。由该基因编码的蛋白质是GDNF受体家族的成员。它是GDNF和NTN的糖基磷脂酰肌醇（GPI）连接的细胞表面受体，介导RET酪氨酸激酶受体的激活。该编码蛋白优先作为NTN的受体，与它的其他家族成员GDNF家族受体α1相比。该基因是RET相关疾病的候选基因。该基因已发现编码不同亚型的多个转录变体。胶质细胞源性神经营养因子(GDNF)家族的成员，包括GDNF和NTN，在脊椎动物神经元存活和分化的控制中起着重要作用。对NTN的生理反应需要一种新的糖基磷脂酰肌醇连接蛋白NTNRa，它是NTN的细胞表面受体。最近克隆了从人、大鼠、鸡和小鼠中编码nTNRA的cDNA。NTNRa也被称为GDNFRb、Ret配体2(RETL2)或TGF-b相关神经营养因子受体2(TrnR2)，最近被命名为GFRa-2。GFRA-2与NTN结合，并通过NTN和GDNF介导RET受体酪氨酸激酶的激活。因此，NTN、GFRA-2和RET PTK形成复合物来转导NTN信号并介导NTN功能。