ZAP70 monoclonal antibody, clone SBZAP (Biotin)
产品名称： ZAP70 monoclonal antibody, clone SBZAP (Biotin)
英文名称： ZAP70 monoclonal antibody, clone SBZAP (Biotin)
产品编号： MAB5891
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against partial recombinant ZAP70.
- Immunogen:
- Recombinant protein corresponding to amino acids 280-309 of human ZAP70.
- Host:
- Mouse
- Reactivity:
- Human
- Specificity:
- human TCR ζ; Zap-70 (Mr 70 KDa).
- Form:
- Liquid
- Conjugation:
- Biotin
- Isotype:
- IgG1, kappa
- Storage Buffer:
- In PBS (0.5 mg/mL sodium azide)
- Storage Instruction:
- Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes.
van Oers NS, Weiss A.Semin Immunol. 1995 Aug;7(4):227-36.
- 2.
- F2(Pmp)2-TAM zeta 3, a novel competitive inhibitor of the binding of ZAP-70 to the T cell antigen receptor, blocks early T cell signaling.
Wange RL, Isakov N, Burke TR Jr, Otaka A, Roller PP, Watts JD, Aebersold R, Samelson LE.J Biol Chem. 1995 Jan 13;270(2):944-8.
- Application Image
- ELISA
- Flow Cytometry
- Entrez GeneID:
- 7535
- Gene Name:
- ZAP70
- Gene Alias:
- FLJ17670,FLJ17679,SRK,STD,TZK,ZAP-70
- Gene Description:
- zeta-chain (TCR) associated protein kinase 70kDa
- Omim ID:
- 176947
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- syk-related tyrosine kinase,zeta-chain (TCR) associated protein kinase (70 kD),zeta-chain associated protein kinase 70kDa,zeta-chain associated protein kinase, 70kD
- Related Disease